Terbinafine resistance conferred by multiple copies of the salicylate 1-monooxygenase gene in Trichophyton rubrum.
Med Mycol
; 56(3): 378-381, 2018 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-28582544
ABSTRACT
Resistance to antifungals is a leading concern in the treatment of human mycoses. We demonstrate that the salA gene, encoding salicylate 1-monooxygenase, is involved in resistance of the dermatophyte Trichophyton rubrum to terbinafine, one of the most effective antifungal drugs against dermatophytes. A strain with multiple copies of salA was constructed and exhibited elevated expression of salA and increased terbinafine resistance. This reflects a mechanism not yet reported in a pathogenic fungus.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Trichophyton
/
Farmacorresistência Fúngica
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Terbinafina
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Oxigenases de Função Mista
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article