Pharmacodynamic Optimization for Treatment of Invasive Candida auris Infection.
Antimicrob Agents Chemother
; 61(8)2017 08.
Article
em En
| MEDLINE
| ID: mdl-28584152
ABSTRACT
Candida auris is an emerging multidrug-resistant threat. The pharmacodynamics of three antifungal classes against nine C. auris strains was explored using a murine invasive candidiasis model. The total drug median pharmacodynamic (PD) target associated with net stasis was a fluconazole AUC/MIC (the area under the concentration-time curve over 24 h in the steady state divided by the MIC) of 26, an amphotericin B Cmax/MIC (maximum concentration of drug in serum divided by the MIC) of 0.9, and a micafungin AUC/MIC of 54. The micafungin PD targets for C. auris were ≥20-fold lower than those of other Candida species in this animal model. Clinically relevant micafungin exposures produced the most killing among the three classes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Candida
/
Candidíase
/
Fluconazol
/
Anfotericina B
/
Equinocandinas
/
Lipopeptídeos
/
Candidíase Invasiva
/
Antifúngicos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article