Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions.
Nat Commun
; 8: 15594, 2017 06 08.
Article
em En
| MEDLINE
| ID: mdl-28593939
ABSTRACT
The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising from disease states such as pathological angiogenesis and inflammatory response. Here we show that the permeability of vascular endothelium can be increased using an external magnetic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the paracellular transport pathway and facilitating the local extravasation of circulating substances. This approach provides a physically controlled drug delivery method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delivery in a broad range of biomedical research and therapeutic applications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Permeabilidade Capilar
/
Endotélio Vascular
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Sistemas de Liberação de Medicamentos
/
Junções Aderentes
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Campos Magnéticos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article