Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.

Liu, Feng; Dawadi, Surendra; Maize, Kimberly M; Dai, Ran; Park, Sae Woong; Schnappinger, Dirk; Finzel, Barry C; Aldrich, Courtney C

Liu, Feng; Dawadi, Surendra; Maize, Kimberly M; Dai, Ran; Park, Sae Woong; Schnappinger, Dirk; Finzel, Barry C; Aldrich, Courtney C.

Afiliação

Liu F; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Dawadi S; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Maize KM; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Dai R; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Park SW; Department of Microbiology and Immunology, Weill Cornell Medical College , New York, New York 10065, United States.
Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medical College , New York, New York 10065, United States.
Finzel BC; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Aldrich CC; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.

J Med Chem ; 60(13): 5507-5520, 2017 07 13.

Article em En | MEDLINE | ID: mdl-28594172

Assuntos

Antibacterianos/farmacologia; Proteínas de Bactérias/antagonistas & inibidores; Biotina/biossíntese; Mycobacterium tuberculosis/efeitos dos fármacos; Piperazinas/farmacologia; Fosfato de Piridoxal/metabolismo; Transaminases/antagonistas & inibidores; Antibacterianos/síntese química; Antibacterianos/química; Proteínas de Bactérias/metabolismo; Biocatálise; Relação Dose-Resposta a Droga; Testes de Sensibilidade Microbiana; Estrutura Molecular; Mycobacterium tuberculosis/metabolismo; Piperazinas/síntese química; Piperazinas/química; Relação Estrutura-Atividade; Transaminases/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Fosfato de Piridoxal / Proteínas de Bactérias / Biotina / Transaminases / Antibacterianos / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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