[Sirt1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response].
Zhonghua Yi Xue Za Zhi
; 97(21): 1659-1663, 2017 Jun 06.
Article
em Zh
| MEDLINE
| ID: mdl-28606256
ABSTRACT
Objective:
To investigate the mechanism of inflammation of smooth muscle cells induced by oxidized low-density lipoprotein through Sirt1 in the atherosclerosis.Methods:
The expression of Sirt1 had been measured in the plaque tissues of human and mice. The affection of overexpression of SIRT1 on the oxLDL induced-inflammatory response and ROS generation had been detected in this study.Results:
Sirt1 decreased in smooth muscle cells region of human plaque. And in the smooth muscle cells region of mice plaque, Sirt1 was also significantly decreased about 5-fold (P<0.05). Although, oxLDL promoted inflammatory cytokines secretion and ROS generation, but this affection had been reversed by upregulating Sirt1.Conclusion:
oxLDL regulated smooth muscle cells inflammatory response via Sirt1. Thus, Sirt1 is a signaling molecular regulating smooth muscles inflammatory response in the process of atherosclerosis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Miócitos de Músculo Liso
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Aterosclerose
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Sirtuína 1
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Músculo Liso Vascular
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article