Hypermethylated CpG sites in the MTR gene promoter in preterm placenta.

Khot, Vinita V; Yadav, Dilip K; Shrestha, Smeeta; Kaur, Lovejeet; Sundrani, Deepali P; Chavan-Gautam, Preeti M; Mehendale, Savita S; Chandak, Giriraj R; Joshi, Sadhana R

Khot, Vinita V; Yadav, Dilip K; Shrestha, Smeeta; Kaur, Lovejeet; Sundrani, Deepali P; Chavan-Gautam, Preeti M; Mehendale, Savita S; Chandak, Giriraj R; Joshi, Sadhana R.

Afiliação

Khot VV; Departments of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, Maharashtra, India.
Yadav DK; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular & Molecular Biology (CSIR-CCMB), Habsiguda, Uppal Road, Hyderabad 500007, Telangana, India.
Shrestha S; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular & Molecular Biology (CSIR-CCMB), Habsiguda, Uppal Road, Hyderabad 500007, Telangana, India.
Kaur L; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular & Molecular Biology (CSIR-CCMB), Habsiguda, Uppal Road, Hyderabad 500007, Telangana, India.
Sundrani DP; Departments of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, Maharashtra, India.
Chavan-Gautam PM; Departments of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, Maharashtra, India.
Mehendale SS; Obstetrics & Gynecology, Bharati Medical College & Hospital, Bharati Vidyapeeth University, Pune 411043, Maharashtra, India.
Chandak GR; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular & Molecular Biology (CSIR-CCMB), Habsiguda, Uppal Road, Hyderabad 500007, Telangana, India.
Joshi SR; Departments of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, Maharashtra, India.

Epigenomics ; 9(7): 985-996, 2017 07.

Article em En | MEDLINE | ID: mdl-28617183

Assuntos

5-Metiltetra-Hidrofolato-Homocisteína S-Metiltransferase/genética; Metilação de DNA; Doenças Placentárias/genética; Nascimento Prematuro/genética; Regiões Promotoras Genéticas; 5-Metiltetra-Hidrofolato-Homocisteína S-Metiltransferase/sangue; Adulto; Estudos de Casos e Controles; Ilhas de CpG; Feminino; Ácido Fólico/sangue; Humanos; Metilenotetra-Hidrofolato Redutase (NADPH2)/sangue; Metilenotetra-Hidrofolato Redutase (NADPH2)/genética; Placenta/metabolismo; Doenças Placentárias/patologia; Gravidez; Nascimento Prematuro/patologia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Vitamina B 12/sangue

Palavras-chave

DNA methylation; MTHFR; MTR; epigenetics; micronutrients; one-carbon metabolism; placenta; preterm pregnancy; remethylation pathway; transcription factors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Placentárias / 5-Metiltetra-Hidrofolato-Homocisteína S-Metiltransferase / Regiões Promotoras Genéticas / Metilação de DNA / Nascimento Prematuro Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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