Lab on paper chip integrated with Si@GNRs for electroanalysis of diazepam.
Anal Chim Acta
; 980: 50-57, 2017 Aug 08.
Article
em En
| MEDLINE
| ID: mdl-28622803
ABSTRACT
We describe herein the fabrication of an electrochemical microfluidic paper based device (EµPAD) for the detection of diazepam, a sedative, anxiety-relieving and muscle-relaxing drug. To achieve it, silica coated gold nanorods (Si@GNRs) were synthesized and drop casted on an electrochemical microfluidic paper based device (EµPAD) for the detection of diazepam. The synthesized composites were characterized by recording its images in scanning electron microscope (SEM) and transmission electron microscope (TEM). The experimental results confirmed that Si@GNRs had good electrocatalytic activity towards diazepam. The modified paper based electrode showed a stable electrochemical response for diazepam in the concentration range of 3.5 nM to 3.5 mM. EµPAD offers many advantageous features such as facile approach, economical and have potential for commercialization. Si@GNRs modified EµPAD was also employed for determination of diazepam in spiked human urine samples. Reported facile lab paper approach integrated with Si@GNRs could be well applied for the determination of serum metabolites.
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Base de dados:
MEDLINE
Assunto principal:
Nanotubos
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Diazepam
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Técnicas Eletroquímicas
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Dispositivos Lab-On-A-Chip
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article