Accumulation properties of polychlorinated biphenyl congeners in Yusho patients and prediction of their cytochrome P450-dependent metabolism by in silico analysis.

Hirakawa, Shusaku; Miyawaki, Takashi; Hori, Tsuguhide; Kajiwara, Jumboku; Katsuki, Susumu; Hirano, Masashi; Yoshinouchi, Yuka; Iwata, Hisato; Mitoma, Chikage; Furue, Masutaka

Hirakawa, Shusaku; Miyawaki, Takashi; Hori, Tsuguhide; Kajiwara, Jumboku; Katsuki, Susumu; Hirano, Masashi; Yoshinouchi, Yuka; Iwata, Hisato; Mitoma, Chikage; Furue, Masutaka.

Afiliação

Hirakawa S; Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, 818-0135, Japan. s-hirakawa@fihes.pref.fukuoka.jp.
Miyawaki T; Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, 818-0135, Japan.
Hori T; Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, 818-0135, Japan.
Kajiwara J; Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, 818-0135, Japan.
Katsuki S; Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, 818-0135, Japan.
Hirano M; Kumamoto College, National Institute of Technology, 2627 Hirayamashin-Machi, Yatsushiro, Kumamoto, 866-8501, Japan.
Yoshinouchi Y; Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama, 790-8577, Japan.
Iwata H; Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama, 790-8577, Japan.
Mitoma C; Research and Clinical Center for Yusho and Dioxin, Kyusyu University Hospital, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Furue M; Research and Clinical Center for Yusho and Dioxin, Kyusyu University Hospital, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

Environ Sci Pollut Res Int ; 25(17): 16455-16463, 2018 Jun.

Article em En | MEDLINE | ID: mdl-28639016

Assuntos

Citocromo P-450 CYP1A2/química; Sistema Enzimático do Citocromo P-450/química; Dioxinas/química; Bifenilos Policlorados/química; Citocromo P-450 CYP1A1/química; Citocromo P-450 CYP1A1/metabolismo; Citocromo P-450 CYP1A2/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Feminino; Humanos; Isoenzimas; Japão; Masculino; Bifenilos Policlorados/sangue

Palavras-chave

Cytochrome P450; Docking simulation; Metabolism; Polychlorinated biphenyl

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bifenilos Policlorados / Citocromo P-450 CYP1A2 / Sistema Enzimático do Citocromo P-450 / Dioxinas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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