Multiparametric voxel-based analyses of standardized uptake values and apparent diffusion coefficients of soft-tissue tumours with a positron emission tomography/magnetic resonance system: Preliminary results.
Eur Radiol
; 27(12): 5024-5033, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28639049
ABSTRACT
OBJECTIVES:
To investigate the usefulness of voxel-based analysis of standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) for evaluating soft-tissue tumour malignancy with a PET/MR system.METHODS:
Thirty-five subjects with either ten low/intermediate-grade tumours or 25 high-grade tumours were prospectively enrolled. Zoomed diffusion-weighted and fluorodeoxyglucose (18FDG)-PET images were acquired along with fat-suppressed T2-weighted images (FST2WIs). Regions of interest (ROIs) were drawn on FST2WIs including the tumour in all slices. ROIs were pasted onto PET and ADC-maps to measure SUVs and ADCs within tumour ROIs. Tumour volume, SUVmax, ADCminimum, the heterogeneity and the correlation coefficients of SUV and ADC were recorded. The parameters of high- and low/intermediate-grade groups were compared, and receiver operating characteristic (ROC) analysis was also performed.RESULTS:
The mean correlation coefficient for SUV and ADC in high-grade sarcomas was lower than that of low/intermediate-grade tumours (-0.41 ± 0.25 vs. -0.08 ± 0.34, P < 0.01). Other parameters did not differ significantly. ROC analysis demonstrated that correlation coefficient showed the best diagnostic performance for differentiating the two groups (AUC 0.79, sensitivity 96.0%, specificity 60%, accuracy 85.7%).CONCLUSIONS:
SUV and ADC determined via PET/MR may be useful for differentiating between high-grade and low/intermediate-grade soft tissue tumours. KEY POINTS ⢠PET/MR allows voxel-based comparison of SUVs and ADCs in soft-tissue tumours. ⢠A comprehensive assessment of internal heterogeneity was performed with scatter plots. ⢠SUVmax or ADCminimum could not differentiate high-grade sarcoma from low/intermediate-grade tumours. ⢠Only the correlation coefficient between SUV and ADC differentiated the two groups. ⢠The correlation coefficient showed the best diagnostic performance by ROC analysis.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Neoplasias de Tecidos Moles
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article