Development of Therapeutic dsP21-322 for Cancer Treatment.
Adv Exp Med Biol
; 983: 217-229, 2017.
Article
em En
| MEDLINE
| ID: mdl-28639203
ABSTRACT
Small activating RNAs (saRNAs) are a class of artificially designed short duplex RNAs targeted at the promoter of a particular gene to upregulate its expression via a mechanism known as RNA activation (RNAa) and hold great promise for treating a wide variety of diseases including those undruggable by conventional therapies. The therapeutic benefits of saRNAs have been demonstrated in a number of preclinical studies carried out in different disease models including cancer. With many tumor suppressor genes (TSGs) downregulated due to either epigenetic mechanisms or haploinsufficiency resulting from deletion/mutation, cancer is an ideal disease space for saRNA therapeutics which can restore the expression of TSGs via epigenetic reprogramming. The p21WAF1/CIP gene is a TSG frequently downregulated in cancer and an saRNA for p21WAF1/CIP known as dsP21-322 has been identified to be a sequence-specific p21WAF1/CIP activator in a number of cancer types. In this chapter, we review preclinical development of medicinal dsP21-322 for cancer, especially prostate cancer and bladder cancer, and highlight its potential for further clinical development.
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MEDLINE
Assunto principal:
Neoplasias da Próstata
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Neoplasias da Bexiga Urinária
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RNA de Cadeia Dupla
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Pequeno RNA não Traduzido
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article