Transgelin-2: A potential oncogenic factor.
Tumour Biol
; 39(6): 1010428317702650, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28639888
ABSTRACT
Actin-binding proteins are proteins that could bind to actin or actin fibers. As a member of actin-binding proteins, Transgelin-2 is expressed in smooth muscle cells and non-smooth muscle cells, and its gene, TAGLN2, is differently expressed in all cells and tissues. The deregulation of Transgelin-2 is considered to be correlated with progression of many kinds of diseases, especially the development of malignant tumors, such as invasion, metastasis, and resistance, yet the function and mechanism of action of Transgelin-2 remain elusive. Therefore, we reviewed the basic characteristics and function of Transgelin-2 and its biological role in various types of diseases in order to provide the theoretical basis for further research and new perspectives on cancer development.
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MEDLINE
Assunto principal:
Biomarcadores Tumorais
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Carcinogênese
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Proteínas dos Microfilamentos
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Proteínas Musculares
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Neoplasias
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article