Characterisation of blood-derived exosomal hTERT mRNA secretion in cancer patients: a potential pan-cancer marker.
Br J Cancer
; 117(3): 353-357, 2017 Jul 25.
Article
em En
| MEDLINE
| ID: mdl-28641311
ABSTRACT
BACKGROUND:
Telomerase (human telomerase reverse transcriptase (hTERT)) is considered a hallmark of cancer. The aim of our study was to evaluate the feasibility of the detection of hTERT transcripts in serum as a 'pan-cancer' diagnostic method.METHODS:
Human telomerase reverse transcriptase mRNA levels were determined in serum and serum-derived exosomes from 133 patients with different malignancies and 45 healthy controls. In four patients hTERT mRNA levels were measured in different clinical stages.RESULTS:
Human telomerase reverse transcriptase transcript was absent in all controls and was variably detected in 67.5% of patients with all cancer types. A correlation between hTERT transcript levels and the clinical course was found in several cases.CONCLUSIONS:
Human telomerase reverse transcriptase mRNA levels may reflect the tumour burden and the clinical status of the patient. In patients with detectable levels, this assay may potentially serve as a diagnostic and follow-up 'pan-cancer' marker. Owing to the large variety of patients and small sample size in each diagnosis, the statistical power is limited and will be explored further in larger groups.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
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Biomarcadores Tumorais
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Telomerase
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Neoplasias
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article