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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.
Dütting, Sebastian; Gaits-Iacovoni, Frederique; Stegner, David; Popp, Michael; Antkowiak, Adrien; van Eeuwijk, Judith M M; Nurden, Paquita; Stritt, Simon; Heib, Tobias; Aurbach, Katja; Angay, Oguzhan; Cherpokova, Deya; Heinz, Niels; Baig, Ayesha A; Gorelashvili, Maximilian G; Gerner, Frank; Heinze, Katrin G; Ware, Jerry; Krohne, Georg; Ruggeri, Zaverio M; Nurden, Alan T; Schulze, Harald; Modlich, Ute; Pleines, Irina; Brakebusch, Cord; Nieswandt, Bernhard.
Afiliação
  • Dütting S; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Gaits-Iacovoni F; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Stegner D; INSERM UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires-I2MC, UMR1048, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse, 1 Avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
  • Popp M; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Antkowiak A; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • van Eeuwijk JMM; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Nurden P; INSERM UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires-I2MC, UMR1048, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse, 1 Avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
  • Stritt S; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Heib T; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Aurbach K; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Angay O; Institut Hospitalo-Universitaire LIRYC, Plateforme Technologique d'Innovation Biomédicale, Hôpital Xavier Arnozan, Avenue du Haut Lévêque, 33604 Pessac, France.
  • Cherpokova D; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Heinz N; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Baig AA; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Gorelashvili MG; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Gerner F; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Heinze KG; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Ware J; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Krohne G; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Ruggeri ZM; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Nurden AT; Research Group for Gene Modification in Stem Cells, LOEWE Center for Cell and Gene Therapy Frankfurt/Main and the Paul-Ehrlich-Institute, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
  • Schulze H; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Modlich U; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Pleines I; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Brakebusch C; Rudolf Virchow Center, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  • Nieswandt B; Institute of Experimental Biomedicine, University Hospital and University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
Nat Commun ; 8: 15838, 2017 06 15.
Article em En | MEDLINE | ID: mdl-28643773
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plaquetas / Complexo Glicoproteico GPIb-IX de Plaquetas / Proteína cdc42 de Ligação ao GTP / Proteína rhoA de Ligação ao GTP Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plaquetas / Complexo Glicoproteico GPIb-IX de Plaquetas / Proteína cdc42 de Ligação ao GTP / Proteína rhoA de Ligação ao GTP Idioma: En Ano de publicação: 2017 Tipo de documento: Article