SIRT4 Is a Regulator of Insulin Secretion.

Zaganjor, Elma; Vyas, Sejal; Haigis, Marcia C

Zaganjor, Elma; Vyas, Sejal; Haigis, Marcia C.

Afiliação

Zaganjor E; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Vyas S; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Haigis MC; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: marcia_haigis@hms.harvard.edu.

Cell Chem Biol ; 24(6): 656-658, 2017 Jun 22.

Article em En | MEDLINE | ID: mdl-28644956

ABSTRACT

ABSTRACT

In a recent issue of Cell Metabolism, Anderson et al. (2017) report that SIRT4 regulates insulin sensitivity in the pancreas via activation of methylcrotonyl-CoA carboxylase 1 (MCCC1) by removal of dicarboxyacyl-lysine modifications. Thus, SIRT4 activates leucine catabolism and causes decreased secretion of insulin from the pancreas.

Assuntos

Insulina/metabolismo; Sirtuínas/metabolismo; Animais; Carbono-Carbono Ligases/metabolismo; Resistência à Insulina; Secreção de Insulina; Camundongos; Pâncreas/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sirtuínas / Insulina Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sirtuínas / Insulina Idioma: En Ano de publicação: 2017 Tipo de documento: Article