Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis.
Eur J Pharmacol
; 811: 260-267, 2017 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-28663035
ABSTRACT
Chronic pain is the most prominent and disabling symptom in the patients with osteoarthritis (OA), and the underlying mechanism largely remains unclear. Interleukin-6 (IL-6), a proinflammatory cytokine, is critically involved in the development and maintenance of central sensitization in several rodent models of chronic pain. The present study aims to elucidate the IL-6 mediated neurological adaptation in dorsal horn in the rat with monosodium iodoacetate (MIA) - induced OA. Significant upregulation of IL-6 expression was detected in the dorsal horn in the modeled rats. Blockade of IL-6 function by tocilizumab markedly suppressed the activation of astrocytes and microglia in the ipsilateral dorsal horn, reduced c-Fos immunoreactivity in dorsal horn neurons, and attenuated the upregulation of glutamate receptor subunits GluR1 and NR2B in dorsal horn in the rats with MIA-induced OA. It was further reported that administration of tocilizumab significantly improved the performance in weight-bearing test and mitigated the mechanical allodynia in the modeled rats. These data illustrated spinal IL-6 mediated mechanism underlying the chronic pain, and proposed the potential therapeutic effect of tocilizumab on the chronic pain in the setting of OA.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
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Dor
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Comportamento Animal
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Interleucina-6
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Corno Dorsal da Medula Espinal
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article