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The influence of high intensity exercise and the Val66Met polymorphism on circulating BDNF and locomotor learning.
Helm, Erin E; Matt, Kathleen S; Kirschner, Kenneth F; Pohlig, Ryan T; Kohl, Dave; Reisman, Darcy S.
Afiliação
  • Helm EE; Biomechanics and Movement Science Program, University of Delaware, Newark DE, United States.
  • Matt KS; College of Health Sciences, University of Delaware, Newark, DE, United States.
  • Kirschner KF; College of Health Sciences, University of Delaware, Newark, DE, United States.
  • Pohlig RT; Biostatistics Core Facility, University of Delaware, Newark, DE, United States.
  • Kohl D; Christiana Care, Newark, DE, United States.
  • Reisman DS; Department of Physical Therapy, University of Delaware, Newark, DE, United States; Biomechanics and Movement Science Program, University of Delaware, Newark DE, United States. Electronic address: dreisman@udel.edu.
Neurobiol Learn Mem ; 144: 77-85, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28668279
Brain-derived neurotrophic factor (BDNF) has been directly related to exercise-enhanced motor performance in the neurologically injured animal model; however literature concerning the role of BDNF in the enhancement of motor learning in the human population is limited. Previous studies in healthy subjects have examined the relationship between intensity of an acute bout of exercise, increases in peripheral BDNF and motor learning of a simple isometric upper extremity task. The current study examined the role of high intensity exercise on upregulation of peripheral BDNF levels as well as the role of high intensity exercise in mediation of motor learning and retention of a novel locomotor task in neurologically intact adults. In addition, the impact of a single nucleotide polymorphism in the BDNF gene (Val66Met) in moderating the relationship between exercise and motor learning was explored. It was hypothesized that participation in high intensity exercise prior to practicing a novel walking task (split-belt treadmill walking) would elicit increases in peripheral BDNF as well as promote an increased rate and magnitude of within session learning and retention on a second day of exposure to the walking task. Within session learning and retention would be moderated by the presence or absence of Val66Met polymorphism. Fifty-four neurologically intact participants participated in two sessions of split-belt treadmill walking. Step length and limb phase were measured to assess learning of spatial and temporal parameters of walking. Serum BDNF was collected prior to and immediately following either high intensity exercise or 5min of quiet rest. The results demonstrated that high intensity exercise provides limited additional benefit to learning of a novel locomotor pattern in neurologically intact adults, despite increases in circulating BDNF. In addition, presence of a single nucleotide polymorphism on the BDNF gene did not moderate the magnitude of serum BDNF increases with high intensity exercise, nor did it moderate the relationship between high intensity exercise and locomotor learning.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exercício Físico / Fator Neurotrófico Derivado do Encéfalo / Aprendizagem / Locomoção / Atividade Motora Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exercício Físico / Fator Neurotrófico Derivado do Encéfalo / Aprendizagem / Locomoção / Atividade Motora Idioma: En Ano de publicação: 2017 Tipo de documento: Article