The transferrin receptor: the cellular iron gate.
Metallomics
; 9(10): 1367-1375, 2017 10 18.
Article
em En
| MEDLINE
| ID: mdl-28671201
ABSTRACT
The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels. In this review, we have discussed the latest advances in the molecular regulation of TfR1 expression and we have considered current understanding of TfR1 function beyond its canonical role in providing iron for erythroid precursors and rapidly proliferating cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores da Transferrina
/
Transferrina
/
Homeostase
/
Ferro
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article