Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy.

Kishton, Rigel J; Sukumar, Madhusudhanan; Restifo, Nicholas P

Kishton, Rigel J; Sukumar, Madhusudhanan; Restifo, Nicholas P.

Afiliação

Kishton RJ; Center for Cell-Based Therapy, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address: rigel.kishton@nih.gov.
Sukumar M; Center for Cell-Based Therapy, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Restifo NP; Center for Cell-Based Therapy, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address: restifon@nih.gov.

Cell Metab ; 26(1): 94-109, 2017 Jul 05.

Article em En | MEDLINE | ID: mdl-28683298

Assuntos

Imunoterapia/métodos; Redes e Vias Metabólicas; Neoplasias/metabolismo; Neoplasias/terapia; Linfócitos T/metabolismo; Animais; Diferenciação Celular; Sobrevivência Celular; Epigênese Genética; Humanos; Imunidade Celular; Neoplasias/genética; Neoplasias/imunologia; Linfócitos T/citologia; Linfócitos T/imunologia; Microambiente Tumoral

Palavras-chave

T cell metabolism; aging; cancer; checkpoint inhibitor; differentiation; epigenetics; immunotherapy; longevity; memory; tumor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Redes e Vias Metabólicas / Imunoterapia / Neoplasias Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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