Preparation, Structure, and Potent Antifouling Activity of Sclerotioramine Derivatives.
Mar Biotechnol (NY)
; 19(4): 372-378, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28688034
ABSTRACT
A series of 30 sclerotioramine derivatives (2-31) of the natural compound, (+)-sclerotiorin (1), has been successfully semi-synthesized by a one-step reaction with high yields (up to 80%). The structures of these new derivatives were established by extensive spectroscopic methods and single-crystal X-ray diffraction analysis for 3, 6, and 10. (+)-Sclerotiorin (1) and its semisynthetic derivatives (2-31) were evaluated for their antifouling activity. Most of them except 6, 7, 8, 12, and 28 showed potent antifouling activity against the larval settlement of the barnacle Balanus amphitrite. More interestingly, most of the aromatic amino-derivatives (13-17, 19-21, 23, 25-27, and 29-31) showed strong antifouling activity; however, only two aliphatic amino-derivatives (5 and 10) had the activity.
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Base de dados:
MEDLINE
Assunto principal:
Thoracica
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Benzopiranos
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Incrustação Biológica
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article