Venom-derived peptide inhibitors of voltage-gated potassium channels.
Neuropharmacology
; 127: 124-138, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28689025
ABSTRACT
Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations in these channels or from autoimmune attack on the channels. Voltage-gated potassium channels are also the target of a broad range of peptide toxins from venomous organisms, including sea anemones, scorpions, spiders, snakes and cone snails; many of these peptides bind to the channels with high potency and selectivity. In this review we describe the various classes of peptide toxins that block these channels and illustrate the broad range of three-dimensional structures that support channel blockade. The therapeutic opportunities afforded by these peptides are also highlighted. This article is part of the Special Issue entitled 'Venom-derived Peptides as Pharmacological Tools.'
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Peçonhas
/
Canais de Potássio de Abertura Dependente da Tensão da Membrana
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Bloqueadores dos Canais de Potássio
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article