Longitudinal community walking activity in Duchenne muscular dystrophy.
Muscle Nerve
; 57(3): 401-406, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-28692198
ABSTRACT
INTRODUCTION:
Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation.METHODS:
Step activity (SA) monitors quantified community ambulation in 42 boys (ages 4-16 years) with DMD with serial enrollment up to 5 years by using a repeated-measures mixed model. Additionally, data were compared with 10-meter walk/run (10mWR) speed to determine validity and sensitivity.RESULTS:
There were significant declines in average strides/day and percent strides at moderate, high and pediatric high rates as a function of age (P < 0.05). Significant correlations for 10mWR versus high and low stride rates were found at baseline (P < 0.05). SA outcomes were sensitive to change over 1 year, but the direction and parameter differed by age group (younger vs. older). Changes in strides/day and percentages of high frequency and low frequency strides correlated significantly with changes in 10mWR speed (P < 0.05).DISCUSSION:
Community ambulation data provide valid and sensitive real-world measures that may inform clinical trials. Muscle Nerve 57 401-406, 2018.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Caminhada
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Distrofia Muscular de Duchenne
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Marcha
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article