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A novel C-type lectin gene is a strong candidate gene for Benedenia disease resistance in Japanese yellowtail, Seriola quinqueradiata.
Nakamoto, Masatoshi; Takeuchi, Yusuke; Akita, Kazuki; Kumagai, Ryo; Suzuki, Junpei; Koyama, Takashi; Noda, Tsutomu; Yoshida, Kazunori; Ozaki, Akiyuki; Araki, Kazuo; Sakamoto, Takashi.
Afiliação
  • Nakamoto M; Department of Aquatic Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.
  • Takeuchi Y; Department of Aquatic Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.
  • Akita K; Department of Aquatic Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.
  • Kumagai R; Department of Aquatic Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.
  • Suzuki J; Department of Aquatic Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.
  • Koyama T; Department of Aquatic Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.
  • Noda T; Goto Laboratory of the Seikai National Fisheries Research Institute, Japan Fisheries Research and Education Agency, Nagasaki 853-0508, Japan.
  • Yoshida K; Goto Laboratory of the Seikai National Fisheries Research Institute, Japan Fisheries Research and Education Agency, Nagasaki 853-0508, Japan.
  • Ozaki A; National Research Institute of Aquaculture, Japan Fisheries Research and Education Agency, Mie 516-0193, Japan.
  • Araki K; National Research Institute of Aquaculture, Japan Fisheries Research and Education Agency, Mie 516-0193, Japan.
  • Sakamoto T; Department of Aquatic Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan. Electronic address: takashis@kaiyodai.ac.jp.
Dev Comp Immunol ; 76: 361-369, 2017 11.
Article em En | MEDLINE | ID: mdl-28705457
ABSTRACT
Little is known about mechanisms of resistance to parasitic diseases in marine finfish. Benedenia disease is caused by infection by the monogenean parasite Benedenia seriolae. Previous quantitative trait locus (QTL) analyses have identified a major QTL associated with resistance to Benedenia disease in linkage group Squ2 of the Japanese yellowtail/amberjack Seriola quinqueradiata. To uncover the bioregulatory mechanism of Benedenia disease resistance, complete Illumina sequencing of BAC clones carrying genomic DNA for the QTL region in linkage group Squ2 was performed to reveal a novel C-type lectin in this region. Expression of the mRNA of this C-type lectin was detected in skin tissue parasitized by B. seriolae. Scanning for single nucleotide polymorphisms (SNPs) uncovered a SNP in the C-type lectin/C-type lectin-like domain that was significantly associated with B. seriolae infection levels. These results strongly suggest that the novel C-type lectin gene controls resistance to Benedenia disease in Japanese yellowtails.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Platelmintos / Pele / Perciformes / Infecções por Cestoides / Proteínas de Peixes / Lectinas Tipo C / Doenças dos Peixes Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Platelmintos / Pele / Perciformes / Infecções por Cestoides / Proteínas de Peixes / Lectinas Tipo C / Doenças dos Peixes Idioma: En Ano de publicação: 2017 Tipo de documento: Article