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TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus.
Hurtado-Zavala, Joaquin I; Ramachandran, Binu; Ahmed, Saheeb; Halder, Rashi; Bolleyer, Christiane; Awasthi, Ankit; Stahlberg, Markus A; Wagener, Robin J; Anderson, Kristin; Drenan, Ryan M; Lester, Henry A; Miwa, Julie M; Staiger, Jochen F; Fischer, Andre; Dean, Camin.
Afiliação
  • Hurtado-Zavala JI; Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstrasse 5, Goettingen 37077, Germany.
  • Ramachandran B; Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstrasse 5, Goettingen 37077, Germany.
  • Ahmed S; Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstrasse 5, Goettingen 37077, Germany.
  • Halder R; Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Robert Koch Strasse 40, Göttingen 37075, Germany.
  • Bolleyer C; Department of Epigenetics and Systems Medicine in Neurodegenerative Disease, German Center for Neurodegenerative Disease, University Medical Center Goettingen, Grisebachstrasse 5, Goettingen 37077, Germany.
  • Awasthi A; Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstrasse 5, Goettingen 37077, Germany.
  • Stahlberg MA; Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstrasse 5, Goettingen 37077, Germany.
  • Wagener RJ; Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstrasse 5, Goettingen 37077, Germany.
  • Anderson K; Institute for Neuroanatomy, University Medical Center Goettingen, Kreuzbergring 36, Goettingen 37075, Germany.
  • Drenan RM; Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva CH-1211, Switzerland.
  • Lester HA; Biological Sciences Department, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
  • Miwa JM; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Staiger JF; Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.
  • Fischer A; Biological Sciences Department, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
  • Dean C; Institute for Neuroanatomy, University Medical Center Goettingen, Kreuzbergring 36, Goettingen 37075, Germany.
Nat Commun ; 8: 15878, 2017 07 19.
Article em En | MEDLINE | ID: mdl-28722015
ABSTRACT
TRPV1 is an ion channel activated by heat and pungent agents including capsaicin, and has been extensively studied in nociception of sensory neurons. However, the location and function of TRPV1 in the hippocampus is debated. We found that TRPV1 is expressed in oriens-lacunosum-moleculare (OLM) interneurons in the hippocampus, and promotes excitatory innervation. TRPV1 knockout mice have reduced glutamatergic innervation of OLM neurons. When activated by capsaicin, TRPV1 recruits more glutamatergic, but not GABAergic, terminals to OLM neurons in vitro. When TRPV1 is blocked, glutamatergic input to OLM neurons is dramatically reduced. Heterologous expression of TRPV1 also increases excitatory innervation. Moreover, TRPV1 knockouts have reduced Schaffer collateral LTP, which is rescued by activating OLM neurons with nicotine-via α2ß2-containing nicotinic receptors-to bypass innervation defects. Our results reveal a synaptogenic function of TRPV1 in a specific interneuron population in the hippocampus, where it is important for gating hippocampal plasticity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canais de Cátion TRPV / Hipocampo / Interneurônios Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canais de Cátion TRPV / Hipocampo / Interneurônios Idioma: En Ano de publicação: 2017 Tipo de documento: Article