MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.
Mol Diagn Ther
; 21(6): 633-642, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-28726006
ABSTRACT
Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. In this review, we outline the structure, expression, and regulation of microRNA-21 and its role in fibrotic skin diseases. In future, it may be useful as a prognostic or diagnostic marker. However, there is a significant amount of work required to increase our current understanding of the role of microRNA-21 in skin fibrosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Dermatopatias
/
MicroRNAs
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article