Active hexose-correlated compound enhances extrinsic-pathway-mediated apoptosis of Acute Myeloid Leukemic cells.

Fatehchand, Kavin; Santhanam, Ramasamy; Shen, Brenda; Erickson, Ericka L; Gautam, Shalini; Elavazhagan, Saranya; Mo, Xiaokui; Belay, Tesfaye; Tridandapani, Susheela; Butchar, Jonathan P

Fatehchand, Kavin; Santhanam, Ramasamy; Shen, Brenda; Erickson, Ericka L; Gautam, Shalini; Elavazhagan, Saranya; Mo, Xiaokui; Belay, Tesfaye; Tridandapani, Susheela; Butchar, Jonathan P.

Afiliação

Fatehchand K; Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, United States of America.
Santhanam R; Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America.
Shen B; Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America.
Erickson EL; Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America.
Gautam S; Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America.
Elavazhagan S; Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America.
Mo X; Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America.
Belay T; Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America.
Tridandapani S; School of Arts and Sciences, Bluefield State University, Bluefield, WV, United States of America.
Butchar JP; Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, United States of America.

PLoS One ; 12(7): e0181729, 2017.

Article em En | MEDLINE | ID: mdl-28727820

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Leucemia Mieloide Aguda/tratamento farmacológico; Polissacarídeos/farmacologia; Animais; Apoptose/fisiologia; Western Blotting; Caspase 3/metabolismo; Caspase 8/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Sobrevivência Celular/fisiologia; Relação Dose-Resposta a Droga; Avaliação Pré-Clínica de Medicamentos; Feminino; Leucemia Mieloide Aguda/metabolismo; Camundongos SCID; Monócitos/efeitos dos fármacos; Monócitos/metabolismo; Transplante de Neoplasias; Reação em Cadeia da Polimerase em Tempo Real; Ligante Indutor de Apoptose Relacionado a TNF/metabolismo; Receptor fas/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissacarídeos / Leucemia Mieloide Aguda / Apoptose / Antineoplásicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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