Structural biology of telomerase and its interaction at telomeres.
Curr Opin Struct Biol
; 47: 77-87, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-28732250
ABSTRACT
Telomerase is an RNP that synthesizes the 3' ends of linear chromosomes and is an important regulator of telomere length. It contains a single long non-coding telomerase RNA (TER), telomerase reverse transcriptase (TERT), and other proteins that vary among organisms. Recent progress in structural biology of telomerase includes reports of the first cryo-electron microscopy structure of telomerase, from Tetrahymena, new crystal structures of TERT domains, telomerase RNA structures and models, and identification in Tetrahymena telomerase holoenzyme of human homologues of telomere-associated proteins that have provided a more unified view of telomerase interaction at telomeres as well as insights into the role of telomerase RNA in activity and assembly.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Telômero
/
Telomerase
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article