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One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole.
Umamaheswari, Rajaji; Akilarasan, Muthumariappan; Chen, Shen-Ming; Cheng, Yi-Hui; Mani, Veerappan; Kogularasu, Sakthivel; Al-Hemaid, Fahad M A; Ajmal Ali, M; Liu, Xiaoheng.
Afiliação
  • Umamaheswari R; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
  • Akilarasan M; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
  • Chen SM; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: smchen78@ms15.hinet.net.
  • Cheng YH; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
  • Mani V; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC; Graduate Institute of Biomedical and Biochemical Engineering, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
  • Kogularasu S; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC.
  • Al-Hemaid FMA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • Ajmal Ali M; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • Liu X; Key Laboratory of Education Ministry for Soft Chemistry and Functional Materials, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address: xhliu@mail.njust.edu.cn.
J Colloid Interface Sci ; 505: 1193-1201, 2017 Nov 01.
Article em En | MEDLINE | ID: mdl-28738516
ABSTRACT
We described a three-dimensional Mn3O4 microcubes (3D-Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D-Mn3O4 MCs possess large active area and high conductivity, and 3D-Mn3O4 MCs film modified screen-printed carbon electrode (3D-Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025-8060µM concentration range and the detection limit was 6nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxidos / Comprimidos / Técnicas Biossensoriais / Compostos de Manganês / Eletrodos / Técnicas Eletroquímicas / Neoplasias de Cabeça e Pescoço / Nimorazol Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxidos / Comprimidos / Técnicas Biossensoriais / Compostos de Manganês / Eletrodos / Técnicas Eletroquímicas / Neoplasias de Cabeça e Pescoço / Nimorazol Idioma: En Ano de publicação: 2017 Tipo de documento: Article