Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice.
Biomed Environ Sci
; 30(7): 535-539, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-28756814
ABSTRACT
The aim of the present study is to evaluate the ability and mechanism by which grape seed procyanidin extract (GSPE) relieves arsenic trioxide (As2O3)-induced renal inflammatory injury. Therefore, male Kunming mice were treated with As2O3 and/or GSPE by gavage for 5 weeks. Mice were then sacrificed and inflammatory cytokines of kidneys were examined by ELISA, whereas the expression levels of molecules involved in the nuclear factor (NF)-κB signaling pathway were evaluated by both qRT-PCR and Western blot. Our results indicate that GSPE prevents As2O3-mediated renal inflammatory injury by inhibiting activation of the NF-κB signaling pathway and inflammatory cytokine production, while promoting expression of anti-inflammatory cytokines.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Arsênio
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Proantocianidinas
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Extrato de Sementes de Uva
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Inflamação
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Nefropatias
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article