Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells.

de Vasconcellos, Jaira F; Byrnes, Colleen; Lee, Y Terry; Allwardt, Joshua M; Kaushal, Megha; Rabel, Antoinette; Miller, Jeffery L

de Vasconcellos, Jaira F; Byrnes, Colleen; Lee, Y Terry; Allwardt, Joshua M; Kaushal, Megha; Rabel, Antoinette; Miller, Jeffery L.

Afiliação

de Vasconcellos JF; Molecular Genomics and Therapeutics Section, Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9N311, Bethesda, MD, 20892, USA.
Byrnes C; Molecular Genomics and Therapeutics Section, Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9N311, Bethesda, MD, 20892, USA.
Lee YT; Molecular Genomics and Therapeutics Section, Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9N311, Bethesda, MD, 20892, USA.
Allwardt JM; Molecular Genomics and Therapeutics Section, Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9N311, Bethesda, MD, 20892, USA.
Kaushal M; Molecular Genomics and Therapeutics Section, Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9N311, Bethesda, MD, 20892, USA.
Rabel A; Molecular Genomics and Therapeutics Section, Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9N311, Bethesda, MD, 20892, USA.
Miller JL; Molecular Genomics and Therapeutics Section, Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9N311, Bethesda, MD, 20892, USA. jm7f@nih.gov.

J Transl Med ; 15(1): 169, 2017 08 02.

Article em En | MEDLINE | ID: mdl-28768505

Assuntos

Células-Tronco Hematopoéticas/metabolismo; MicroRNAs/metabolismo; Adulto; Sequência de Bases; Proteínas de Transporte/genética; Proteínas de Transporte/metabolismo; Diferenciação Celular; Proliferação de Células/genética; Células Cultivadas; Hemoglobina Fetal; Regulação da Expressão Gênica; Técnicas de Silenciamento de Genes; Proteína HMGA2/genética; Proteína HMGA2/metabolismo; Células-Tronco Hematopoéticas/citologia; Humanos; MicroRNAs/genética; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Proteínas Repressoras; Reticulócitos/metabolismo; gama-Globinas/genética; gama-Globinas/metabolismo

Palavras-chave

Fetal hemoglobin; Gamma-globin; HbF; let-7; let-7a; let-7b; miRNAs

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / MicroRNAs Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / MicroRNAs Idioma: En Ano de publicação: 2017 Tipo de documento: Article