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Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.
Monahan, Zachary; Ryan, Veronica H; Janke, Abigail M; Burke, Kathleen A; Rhoads, Shannon N; Zerze, Gül H; O'Meally, Robert; Dignon, Gregory L; Conicella, Alexander E; Zheng, Wenwei; Best, Robert B; Cole, Robert N; Mittal, Jeetain; Shewmaker, Frank; Fawzi, Nicolas L.
Afiliação
  • Monahan Z; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University, Bethesda, MD, USA.
  • Ryan VH; Neuroscience Graduate Program, Brown University, Providence, RI, USA.
  • Janke AM; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA.
  • Burke KA; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA.
  • Rhoads SN; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University, Bethesda, MD, USA.
  • Zerze GH; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, USA.
  • O'Meally R; Johns Hopkins Mass Spectrometry and Proteomic Facility, Johns Hopkins University, Baltimore, MD, USA.
  • Dignon GL; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, USA.
  • Conicella AE; Graduate Program in Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
  • Zheng W; Laboratory of Chemical Physics, National Institutes of Health, Bethesda, MD, USA.
  • Best RB; Laboratory of Chemical Physics, National Institutes of Health, Bethesda, MD, USA.
  • Cole RN; Johns Hopkins Mass Spectrometry and Proteomic Facility, Johns Hopkins University, Baltimore, MD, USA.
  • Mittal J; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, USA.
  • Shewmaker F; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University, Bethesda, MD, USA fshewmaker@usuhs.edu nicolas_fawzi@brown.edu.
  • Fawzi NL; Neuroscience Graduate Program, Brown University, Providence, RI, USA fshewmaker@usuhs.edu nicolas_fawzi@brown.edu.
EMBO J ; 36(20): 2951-2967, 2017 10 16.
Article em En | MEDLINE | ID: mdl-28790177
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Proteína FUS de Ligação a RNA Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Proteína FUS de Ligação a RNA Idioma: En Ano de publicação: 2017 Tipo de documento: Article