Enzymatic Synthesis of N-Acetyllactosamine (LacNAc) Type 1 Oligomers and Characterization as Multivalent Galectin Ligands.

Fischöder, Thomas; Laaf, Dominic; Dey, Carina; Elling, Lothar

Fischöder, Thomas; Laaf, Dominic; Dey, Carina; Elling, Lothar.

Afiliação

Fischöder T; Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany. t.fischoeder@biotec.rwth-aachen.de.
Laaf D; Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany. d.laaf@biotec.rwth-aachen.de.
Dey C; Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany. c.dey@biotec.rwth-aachen.de.
Elling L; Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany. l.elling@biotec.rwth-aachen.de.

Molecules ; 22(8)2017 Aug 10.

Article em En | MEDLINE | ID: mdl-28796164

Assuntos

Amino Açúcares/química; Galactosiltransferases/química; Galectina 3/química; Oligossacarídeos/química; Escherichia coli/enzimologia; Glicoproteínas/síntese química; Helicobacter pylori/enzimologia; Humanos; Ligantes; Ligação Proteica; Soroalbumina Bovina/química

Palavras-chave

LacNAc type 1; biocatalysis; chemo-enzymatic synthesis; galectin-3; glycosyltransferase; multivalency; neo-glycoproteins; one-pot; sequential

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Galectina 3 / Galactosiltransferases / Amino Açúcares Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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