Asymmetric Michael Addition Organocatalyzed by α,ß-Dipeptides under Solvent-Free Reaction Conditions.
Molecules
; 22(8)2017 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-28796165
ABSTRACT
The application of six novel α,ß-dipeptides as chiral organocatalysts in the asymmetric Michael addition reaction between enolizable aldehydes and N-arylmaleimides or nitroolefins is described. With N-arylmaleimides as substrates, the best results were achieved with dipeptide 2 as a catalyst in the presence of aq. NaOH. Whereas dipeptides 4 and 6 in conjunction with 4-dimethylaminopyridine (DMAP) and thiourea as a hydrogen bond donor proved to be highly efficient organocatalytic systems in the enantioselective reaction between isobutyraldehyde and various nitroolefins.
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MEDLINE
Assunto principal:
Dipeptídeos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article