[The plasma levels and diagnostic utility of matrix metalloproteinase-9 and CA 125 in cervical cancer patients]. / Ocena stezenia i przydatnosci diagnostycznej metaloproteinazy-9 i CA 125 w osoczu chorych na raka szyjki macicy.
Pol Merkur Lekarski
; 43(253): 10-14, 2017 Jul 21.
Article
em Pl
| MEDLINE
| ID: mdl-28805195
ABSTRACT
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, involved in the degradation of extracellular matrix components. The physiological function of MMP-9 is associated with regulation of immune processes, embryogenesis, reproduction and wound healing. MMP-9 also plays a critical role in tumor invasion, degrading the basement membrane, what is observed in different types of cancers breast, gastrointestinal, and gynecological. AIM:
The aim of this study was to investigate the plasma levels and diagnostic utility of MMP-9 and CA 125 in cervical cancer patients. MATERIALS ANDMETHODS:
The study included 72 patients with cervical cancer and 24 healthy women. Plasma levels of the MMP- 9 was determined by enzyme-linked immunosorbent assay (ELISA) and CA 15-3 - by chemiluminescent microparticle immunoassay (CMIA).RESULTS:
This studies have shown increase levels of MMP-9 and CA 125 in cervical cancer patients compared to health control group. In addition, the MMP-9 concentration increased with the clinical stage of tumor. The sensitivity and specificity of MMP-9, positive and negative predictive value, were higher or equal than CA 125, but this parameter can not be used as a single marker. Our studies of MMP-9 have shown a high utility to the exclusion of cancer, similarly to CA 125. The combined analysis of MMP-9 and CA 125 significantly increased the ability to diagnose a cervical cancer and the possibility exclusion of cancer.CONCLUSIONS:
MMP-9 has shown the usefulness in the diagnosis of cervical cancer, but only in the combined analysis with CA 125, as a new diagnostic panel.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
/
Antígeno Ca-125
/
Metaloproteinase 9 da Matriz
Idioma:
Pl
Ano de publicação:
2017
Tipo de documento:
Article