An environmental pollutant, 9,10-phenanthrenequinone, activates human TRPA1 via critical cysteines 621 and 665.

Muraki, Katsuhiko; Sekine, Takashi; Ando, Yuna; Suzuki, Hiroka; Hatano, Noriyuki; Hirata, Tadashi; Muraki, Yukiko.

Afiliação

Muraki K; Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya, 464-8650, Japan.
Sekine T; Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya, 464-8650, Japan.
Ando Y; R&D Group, Tobacco Business Headquarters, Scientific Product Assessment Center, Japan Tobacco Inc., Yokohama, 227-8512, Japan.
Suzuki H; Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya, 464-8650, Japan.
Hatano N; Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya, 464-8650, Japan.
Hirata T; Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya, 464-8650, Japan.
Muraki Y; R&D Group, Tobacco Business Headquarters, Scientific Product Assessment Center, Japan Tobacco Inc., Yokohama, 227-8512, Japan.

Pharmacol Res Perspect ; 5(4)2017 Aug.

Article em En | MEDLINE | ID: mdl-28805980