Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A<sub>3</sub> Receptor Antagonists.

Xia, Lizi; Burger, Wessel A C; van Veldhoven, Jacobus P D; Kuiper, Boaz J; van Duijl, Tirsa T; Lenselink, Eelke B; Paasman, Ellen; Heitman, Laura H; IJzerman, Adriaan P

Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A₃ Receptor Antagonists.

Xia, Lizi; Burger, Wessel A C; van Veldhoven, Jacobus P D; Kuiper, Boaz J; van Duijl, Tirsa T; Lenselink, Eelke B; Paasman, Ellen; Heitman, Laura H; IJzerman, Adriaan P.

Afiliação

Xia L; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.
Burger WAC; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.
van Veldhoven JPD; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.
Kuiper BJ; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.
van Duijl TT; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.
Lenselink EB; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.
Paasman E; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.
Heitman LH; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.
IJzerman AP; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University , 2300 RA Leiden, The Netherlands.

J Med Chem ; 60(17): 7555-7568, 2017 09 14.

Article em En | MEDLINE | ID: mdl-28806076

Assuntos

Antagonistas do Receptor A3 de Adenosina/química; Antagonistas do Receptor A3 de Adenosina/farmacologia; Purinas/química; Purinas/farmacologia; Receptor A3 de Adenosina/metabolismo; Animais; Células CHO; Cricetulus; Humanos; Cinética; Simulação de Acoplamento Molecular

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Purinas / Receptor A3 de Adenosina / Antagonistas do Receptor A3 de Adenosina Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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