Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition.

Wang, Li-Chao; Liao, Li-Xi; Lv, Hai-Ning; Liu, Dan; Dong, Wei; Zhu, Jian; Chen, Jin-Feng; Shi, Meng-Ling; Fu, Ge; Song, Xiao-Min; Jiang, Yong; Zeng, Ke-Wu; Tu, Peng-Fei

Wang, Li-Chao; Liao, Li-Xi; Lv, Hai-Ning; Liu, Dan; Dong, Wei; Zhu, Jian; Chen, Jin-Feng; Shi, Meng-Ling; Fu, Ge; Song, Xiao-Min; Jiang, Yong; Zeng, Ke-Wu; Tu, Peng-Fei.

Afiliação

Wang LC; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Liao LX; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Lv HN; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Liu D; Proteomics Laboratory, Medical and Healthy Analytical Center, Peking University Health Science Center, Beijing 100191, China.
Dong W; State Key Laboratory of Membrane Biology, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Zhu J; State Key Laboratory of Membrane Biology, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Chen JF; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Shi ML; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Fu G; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Song XM; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Jiang Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Zeng KW; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: ZKW@bjmu.edu.cn.
Tu PF; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: pengfeitu@bjmu.edu.cn.

EBioMedicine ; 23: 160-172, 2017 Sep.

Article em En | MEDLINE | ID: mdl-28807514

Assuntos

Sítio Alostérico; Proteínas de Choque Térmico HSP70/agonistas; Proteínas de Choque Térmico HSP70/química; Relação Quantitativa Estrutura-Atividade; Terpenos/química; Terpenos/farmacologia; Regulação Alostérica; Animais; Sítios de Ligação; Caenorhabditis elegans; Linhagem Celular; Cisteína/química; Citocinas/metabolismo; Ativação Enzimática; Proteínas de Choque Térmico HSP70/genética; Proteínas de Choque Térmico HSP70/metabolismo; Humanos; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Mediadores da Inflamação/metabolismo; Ligantes; Masculino; Camundongos; Modelos Biológicos; Modelos Moleculares; Conformação Molecular; Estrutura Molecular; Mutação; NF-kappa B/metabolismo; Doenças do Sistema Nervoso/tratamento farmacológico; Doenças do Sistema Nervoso/metabolismo; Ligação Proteica; Fator 6 Associado a Receptor de TNF/metabolismo; Ubiquitinação/efeitos dos fármacos; Peixe-Zebra

Palavras-chave

Covalent modification; Drug target; Handelin; Heat shock protein 70 (Hsp70); Neuroinflammation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terpenos / Proteínas de Choque Térmico HSP70 / Relação Quantitativa Estrutura-Atividade / Sítio Alostérico Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google