Epigenetics and Oxidative Stress in Aging.
Oxid Med Cell Longev
; 2017: 9175806, 2017.
Article
em En
| MEDLINE
| ID: mdl-28808499
Aging is a multifactorial process characterized by the progressive loss of physiological functions, leading to an increased vulnerability to age-associated diseases and finally to death. Several theories have been proposed to explain the nature of aging. One of the most known identifies the free radicals produced by the mitochondrial metabolism as the cause of cellular and DNA damage. However, there are also several evidences supporting that epigenetic modifications, such as DNA methylation, noncoding RNAs, and histone modifications, play a critical role in the molecular mechanism of aging. In this review, we explore the significance of these findings and argue how the interlinked effects of oxidative stress and epigenetics can explain the cause of age-related declines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Estresse Oxidativo
/
Epigênese Genética
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article