A new anthracycline-type metabolite from Streptomyces sp. NEAU-L3.
J Antibiot (Tokyo)
; 70(10): 1026-1028, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28811620
ABSTRACT
A new anthracycline-type metabolite, designated as tetracenoquinocin A (1), was isolated from the fermentation broth of Streptomyces sp. NEAU-L3. Its structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. Compound 1 showed potent cytotoxic activity against three cancer cell lines (HepG2, A549, HCT-116) with IC50 values of 5.57, 24.30 and 20.82 µM, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
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Produtos Biológicos
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Antraciclinas
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Antineoplásicos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article