NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory.
Cell Rep
; 20(7): 1572-1584, 2017 08 15.
Article
em En
| MEDLINE
| ID: mdl-28813670
ABSTRACT
The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of cholinergic septohippocampal projection neurons and large subsets of basal forebrain cholinergic neurons. In the absence of NKX2-1, these neurons fail to develop, causing alterations in hippocampal theta rhythms and severe deficiencies in learning and memory. Our results demonstrate that learning and memory are dependent on NKX2-1 function in the embryonic septum and suggest that cognitive deficiencies that are sometimes associated with pathogenic mutations in NKX2-1 in humans may be a direct consequence of loss of NKX2-1 function.
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MEDLINE
Assunto principal:
Regulação da Expressão Gênica no Desenvolvimento
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Septo do Cérebro
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Neurônios Colinérgicos
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Fator Nuclear 1 de Tireoide
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Hipocampo
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Memória
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article