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Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms.
Olmez, Inan; Brenneman, Breanna; Xiao, Aizhen; Serbulea, Vlad; Benamar, Mouadh; Zhang, Ying; Manigat, Laryssa; Abbas, Tarek; Lee, Jeongwu; Nakano, Ichiro; Godlewski, Jakub; Bronisz, Agnieszka; Abounader, Roger; Leitinger, Norbert; Purow, Benjamin.
Afiliação
  • Olmez I; Department of Neurology, University of Virginia, Charlottesville, Virginia.
  • Brenneman B; Department of Neurology, University of Virginia, Charlottesville, Virginia.
  • Xiao A; Department of Neurology, University of Virginia, Charlottesville, Virginia.
  • Serbulea V; Department of Pharmacology, University of Virginia, Charlottesville, Virginia.
  • Benamar M; Department of Radiation Oncology, Biochemistry, and Molecular Genetics, University of Virginia, Charlottesville, Virginia.
  • Zhang Y; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia.
  • Manigat L; Department of Neurology, University of Virginia, Charlottesville, Virginia.
  • Abbas T; Department of Radiation Oncology, Biochemistry, and Molecular Genetics, University of Virginia, Charlottesville, Virginia.
  • Lee J; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
  • Nakano I; Department of Neurosurgery, University of Alabama, Birmingham, Alabama.
  • Godlewski J; Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts.
  • Bronisz A; Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts.
  • Abounader R; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia.
  • Leitinger N; Department of Pharmacology, University of Virginia, Charlottesville, Virginia.
  • Purow B; Department of Neurology, University of Virginia, Charlottesville, Virginia. bwp5g@virginia.edu.
Clin Cancer Res ; 23(22): 6958-6968, 2017 Nov 15.
Article em En | MEDLINE | ID: mdl-28814434
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glioblastoma / Quinase 4 Dependente de Ciclina / Quinase 6 Dependente de Ciclina / Serina-Treonina Quinases TOR Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glioblastoma / Quinase 4 Dependente de Ciclina / Quinase 6 Dependente de Ciclina / Serina-Treonina Quinases TOR Idioma: En Ano de publicação: 2017 Tipo de documento: Article