Renal transplantation in systemic lupus erythematosus: Comparison of graft survival with other causes of end-stage renal disease. / Trasplante renal en lupus eritematoso sistémico: comparación de la supervivencia del injerto con otras causas de enfermedad renal terminal.
Reumatol Clin (Engl Ed)
; 15(3): 140-145, 2019.
Article
em En, Es
| MEDLINE
| ID: mdl-28818581
ABSTRACT
INTRODUCTION:
End-stage renal disease (ESRD) due to lupus nephritis (LN) occurs in 10%-30% of patients. Initially systemic lupus erythematosus (SLE) was a contraindication for kidney transplantation (KT). Today, long-term graft survival remains controversial. Our objective was to compare the survival after KT in patients with SLE or other causes of ESRD.METHODS:
All SLE patients who had undergone KT in a retrospective cohort were included. Renal graft survival was compared with that of 50 controls, matched for age, sex, and year of transplantation. Survival was evaluated by the Kaplan-Meier test and the Cox proportional hazards model.RESULTS:
Twenty-five subjects with SLE were included. The estimated 1-year, 2- and 5-year survival rates for patients with SLE were 92%, 66% and 66%. Renal graft survival did not differ between patients with SLE and other causes of ESRD (P=.39). The multivariate analysis showed no significant difference in graft survival between the two groups (hazard ratio, HR=1.95, 95% confidence interval [CI] 0.57-6.61, P=.28). The recurrence rate of LN was 8% and was not associated with graft loss. Acute rejection was the only variable associated with graft loss in patients with SLE (HR=16.5, 95% CI 1.94-140.1, P=.01).CONCLUSIONS:
Renal graft survival in SLE patients did not differ from that reported for other causes of ESRD.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Sobrevivência de Enxerto
/
Falência Renal Crônica
/
Lúpus Eritematoso Sistêmico
Idioma:
En
/
Es
Ano de publicação:
2019
Tipo de documento:
Article