The role of endothelium in the onset of antibody-mediated TRALI.
Blood Rev
; 32(1): 1-7, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-28823763
ABSTRACT
Transfusion Related Acute Lung Injury (TRALI) is one of the leading causes of mortality and morbidity following blood transfusion. The mechanisms behind the disease are not yet fully understood but seem to involve many different activating pathways and donor factors, in synergy with patient susceptibility. Studies have focused mostly on neutrophil activation, as aggregates of neutrophils and edema in lungs are found in post-mortem histological sections. This review aims to highlight the role of the endothelium in TRALI, as activated endothelium is the main promoter of leukocyte transmigration, and creates the barrier between blood and tissue. Since recent evidence suggests that a strong endothelial barrier prevents leukocyte transmigration and vascular leakage, we suggest that strengthening this barrier may be key to TRALI prevention.
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Base de dados:
MEDLINE
Assunto principal:
Endotélio
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Lesão Pulmonar Aguda Relacionada à Transfusão
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Anticorpos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article