An online adaptive screening procedure for selective neuronal responses.
J Neurosci Methods
; 291: 36-42, 2017 11 01.
Article
em En
| MEDLINE
| ID: mdl-28826654
ABSTRACT
BACKGROUND:
A common problem in neurophysiology is to identify stimuli that elicit neuronal responses in a given brain region. Particularly in situations where electrode positions are fixed, this can be a time-consuming task that requires presentation of a large number of stimuli. Such a screening for response-eliciting stimuli is employed, e.g., as a standard procedure to identify 'concept cells' in the human medial temporal lobe. NEWMETHOD:
Our new method evaluates neuronal responses to stimuli online during a screening session, which allows us to successively exclude stimuli that do not evoke a response. Using this method, we can screen a larger number of stimuli which in turn increases the chances of finding responsive neurons and renders time-consuming offline analysis unnecessary.RESULTS:
Our method enabled us to present 30% more stimuli in the same period of time with additional presentations of the most promising candidate stimuli. Our online method ran smoothly on a standard computer and network. COMPARISON WITH AN EXISTINGMETHOD:
To analyze how our online screening procedure performs in comparison to an established offline method, we used the Wave_Clus software package. We did not observe any major drawbacks in our method, but a much higher efficiency and analysis speed.CONCLUSIONS:
By transitioning from a traditional offline screening procedure to our new online method, we substantially increased the number of visual stimuli presented in a given time period. This allows to identify more response-eliciting stimuli, which forms the basis to better address a great number of questions in cognitive neuroscience.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Algoritmos
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Processamento de Sinais Assistido por Computador
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Encéfalo
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Potenciais de Ação
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Neurônios
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article