Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population.
BMC Med Genet
; 18(1): 90, 2017 08 22.
Article
em En
| MEDLINE
| ID: mdl-28830368
ABSTRACT
BACKGROUND:
There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.METHODS:
A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms.RESULTS:
In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (ß = -3.48; 95%CI-7.11;0.15; p = 0.060), sum of skin fold thickness (ß = -6.53, 95% CI -12.96;-0.11; p = 0.046) as well as total % of body fat (ß = -3.14, 95% CI -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (ß = -4.37, 95% CI -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (ß = -7.77, 95% CI -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too.CONCLUSION:
Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Calcitriol
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Polimorfismo de Nucleotídeo Único
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População Branca
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Adiposidade
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article