Medication contaminants as a potential cause of anaphylaxis to vincristine.
Pediatr Blood Cancer
; 65(1)2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-28834048
ABSTRACT
Vincristine (VCR) is a vinca alkaloid and common chemotherapeutic that is used to treat multiple pediatric and adult malignancies. Despite its common use, cases of anaphylaxis to VCR are rare and typically isolated to a single individual. We report a series of eight patients with adverse reactions to VCR over the course of 11 months at a single institution, four of which progressed to anaphylaxis and one of which resulted in cardiac arrest. Mass spectrometry analysis of medication lots was performed to test for possible contaminant(s). Our findings highlight the risk of anaphylaxis during therapy with VCR.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vincristina
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Contaminação de Medicamentos
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Anafilaxia
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Neoplasias
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article