Aß accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.

Willén, Katarina; Edgar, James R; Hasegawa, Takafumi; Tanaka, Nobuyuki; Futter, Clare E; Gouras, Gunnar K

Willén, Katarina; Edgar, James R; Hasegawa, Takafumi; Tanaka, Nobuyuki; Futter, Clare E; Gouras, Gunnar K.

Afiliação

Willén K; Department of Experimental Medical Science, Lund University, 221 84, Lund, Sweden.
Edgar JR; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
Hasegawa T; UCL Institute of Ophthalmology, London, EC1V 9EL, UK.
Tanaka N; Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Futter CE; Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori, 981-1293, Japan.
Gouras GK; UCL Institute of Ophthalmology, London, EC1V 9EL, UK.

Mol Neurodegener ; 12(1): 61, 2017 08 23.

Article em En | MEDLINE | ID: mdl-28835279

Assuntos

Precursor de Proteína beta-Amiloide/metabolismo; Endossomos/metabolismo; Lisossomos/metabolismo; Corpos Multivesiculares/patologia; Placa Amiloide/patologia; ATPases Associadas a Diversas Atividades Celulares/metabolismo; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Animais; Complexos Endossomais de Distribuição Requeridos para Transporte/metabolismo; Camundongos Transgênicos; Neurônios/metabolismo

Palavras-chave

Alzheimer's disease; Amyloid; Endocytosis; Multivesicular body; Tau

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endossomos / Precursor de Proteína beta-Amiloide / Placa Amiloide / Corpos Multivesiculares / Lisossomos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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