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Immunological effects among workers who handle engineered nanoparticles.
Glass, Deborah Catherine; Mazhar, Mahjabeen; Xiang, Sue; Dean, Pamela; Simpson, Pamela; Priestly, Brian; Plebanski, Magdalena; Abramson, Michael; Sim, Malcolm Ross; Dennekamp, Martine.
Afiliação
  • Glass DC; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, 553 St Kilda Road, Melbourne, Victoria, Australia.
  • Mazhar M; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, 553 St Kilda Road, Melbourne, Victoria, Australia.
  • Xiang S; Department of Immunology and Pathology, Central Clinical School, Faculty of Medicine, Nursing & Health Sciences, Monash University, The Alfred Hospital, Melbourne, Victoria, Australia.
  • Dean P; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, 553 St Kilda Road, Melbourne, Victoria, Australia.
  • Simpson P; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, The Alfred Centre, Melbourne, Victoria, Australia.
  • Priestly B; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, 553 St Kilda Road, Melbourne, Victoria, Australia.
  • Plebanski M; Department of Immunology and Pathology, Central Clinical School, Faculty of Medicine, Nursing & Health Sciences, Monash University, The Alfred Hospital, Melbourne, Victoria, Australia.
  • Abramson M; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, 553 St Kilda Road, Melbourne, Victoria, Australia.
  • Sim MR; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, 553 St Kilda Road, Melbourne, Victoria, Australia.
  • Dennekamp M; Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, 553 St Kilda Road, Melbourne, Victoria, Australia.
Occup Environ Med ; 74(12): 868-876, 2017 12.
Article em En | MEDLINE | ID: mdl-28847906
ABSTRACT

OBJECTIVE:

To determine whether exposure of workers handling engineered nanoparticles (ENPs) may result in increased inflammation and changes in lung function.

METHODS:

A prospective panel study compared changes in several markers of inflammation for ENP handling and non-ENP handling control workers. Nanoparticle exposure was measured during ENP handling and for controls. Lung function, fraction of exhaled nitric oxide (FeNO), C-reactive protein (CRP), blood cell counts and several serum cytokines were measured at baseline, at the end of the shift and at the end of the working week.

RESULTS:

Nanoparticle exposure was not higher when ENPs were being handled; nanoparticle counts were higher in offices and in ambient air than in laboratories. There were no differences at baseline in lung function, FeNO, haemoglobin, platelet, white cell counts or CRP levels between those who handled nanoparticles and those who did not, with or without asthmatic participants. There were statistically significant increases in sCD40 and sTNFR2 over the working day for those who handled ENPs. The changes were larger and statistically significant over the working week and sCD62P also showed a statistically significant difference. The changes were slightly smaller and less likely to be statistically significant for atopic than for non-atopic participants.

CONCLUSIONS:

Even at low ENP exposure, increases in three cytokines were significant over the week for those who handled nanoparticles, compared with those who did not. However, exposure to low and transient levels of nanoparticles was insufficient, to trigger measurable changes in spirometry, FeNO, CRP or blood cell counts.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Exposição Ocupacional / Exposição por Inalação / Nanopartículas / Inflamação / Pulmão / Ocupações Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Exposição Ocupacional / Exposição por Inalação / Nanopartículas / Inflamação / Pulmão / Ocupações Idioma: En Ano de publicação: 2017 Tipo de documento: Article