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Elevated PT, APPT and PT/INR possibly associated with doxycycline and cefoperazone co-administration: A case report.
Zhu, X Q; Guo, C F; Wen, Y G; Shang, D W; Hu, J Q; Deng, S H; Tan, Y; Qiu, C.
Afiliação
  • Zhu XQ; Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
  • Guo CF; Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
  • Wen YG; Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
  • Shang DW; Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
  • Hu JQ; Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
  • Deng SH; Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
  • Tan Y; Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
  • Qiu C; Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
J Clin Pharm Ther ; 43(1): 141-144, 2018 Feb.
Article em En | MEDLINE | ID: mdl-28850701
ABSTRACT
WHAT IS KNOWN AND

OBJECTIVE:

Little is known regarding changes in blood coagulation parameters associated with tetracycline antibiotics. We report a possible case of elevated PT, APPT and PT/INR associated with doxycycline and cefoperazone co-administration. CASE

SUMMARY:

An 83-year-old Chinese male inpatient with severe pneumonia, chronic renal insufficiency and malnutrition experienced elevated PT, APPT and PT/INR which occurred within a few days of doxycycline added to his cefoperazone treatment and returned to normal after removal of it. WHAT IS NEW AND

CONCLUSION:

Very close monitoring of coagulation parameters might be advisable in those subjects when administering doxycycline and cefoperazone concomitantly.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coagulação Sanguínea / Cefoperazona / Doxiciclina / Antibacterianos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coagulação Sanguínea / Cefoperazona / Doxiciclina / Antibacterianos Idioma: En Ano de publicação: 2018 Tipo de documento: Article