Dissociable effects of cocaine and yohimbine on impulsive action and relapse to cocaine seeking.
Psychopharmacology (Berl)
; 234(22): 3343-3351, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28856391
ABSTRACT
RATIONALE A strong association has been demonstrated between various forms of impulsivity and addiction-like behavior in both humans and rats. OBJECTIVES:
In this study, we investigated how impulsive action, as measured in the 5-choice serial reaction time task (5-CSRTT), is affected during various stages of cocaine taking and seeking and by relapse-provoking stimuli in animals that were trained both in an intravenous cocaine self-administration paradigm and in the 5-CSRTT.METHODS:
Rats were concurrently trained in the 5-CSRTT and cocaine self-administration protocol, and subsequently, the effects of cocaine (7.5 mg/kg) and the pharmacological stressor yohimbine (1.25 mg/kg) were tested in both paradigms.RESULTS:
Cocaine self-administration (5 h/day) transiently altered impulsive action and increased errors of omission in the 5-CSRTT. Pharmacological challenges with cocaine and yohimbine induced increments in impulsive action and reinstated cocaine-seeking responses within the same animals. Further analyses revealed that the effects of cocaine and yohimbine on impulsive action did not correlate with their effects on reinstatement of cocaine seeking.CONCLUSIONS:
These data suggest that although impulsive action and relapse can be pharmacologically modulated in the same direction within individuals, these effects appear not to be directly coupled.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ioimbina
/
Cocaína
/
Transtornos Relacionados ao Uso de Cocaína
/
Fissura
/
Comportamento Impulsivo
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article