Cerium-catalyzed, oxidative synthesis of annulated, tetrasubstituted dihydrofuran-derivatives.
Org Biomol Chem
; 15(37): 7824-7829, 2017 Sep 26.
Article
em En
| MEDLINE
| ID: mdl-28876019
ABSTRACT
Densely functionalized, annulated dihydrofuran derivatives are prepared by a cerium-catalyzed aerobic oxidation reaction. The operationally simple transformation is environmentally and economically benign, since the precatalyst CeCl3·7H2O is non-toxic and inexpensive and the oxidant is simply dioxygen from air. Starting materials are ß-oxoesters and silylenolethers, and the latter are derived from acetoacetate or acetylacetone. The reaction sequence is performed in one flask and consists of α-oxidation and Mukaiyama aldol reaction. Apart from tetrahydrocyclopenta[b]furan derivatives one example of a tetrahydrofuro[3,4-b]furan and one tetrahydro-3aH-furo[2,3-c]pyrrole derivative are prepared.
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MEDLINE
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En
Ano de publicação:
2017
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Article